Premature Thelarche and Precocious Puberty in a Three-Year-Old Girl with Granulosa Cell Tumor

Granulosa cell tumors (GCTs) are tumors that arise from granulosa cells, occurring in women 50 to 55 years of age but may occur at any age whereas Juvenile granulosa cell tumors usually occur in children and adolescents. A three years old girl with breast development but without any significant past medical history was referred to the Pediatric Clinic in Children hospital(University of Medical Sciences, Tabriz, Iran) in July 2011.We have reported this patient with premature thelarche and isosexual precocity in this paper. Pelvic ultrasonography showed a hypoechoic solid mass and abdominopelvic MRI showed left adnexal mass with cystic components. Microscopic features of the resected mass were characteristic of juvenile GCT. Although in most of girls with precocious puberty the etiology is idiopathic, some important causes, such as ovarian tumors must be considered because most common presenting manifestation of GCT in children is precocious puberty. 1-General Physician, Islamic Azad University Tabriz Branch, Iran Article History: Received April 2013 Accepted May 2013 Available online July 2013 Corresponding Author: Zahra Ghanbari, General Physician, Islamic Azad University Tabriz Branch, Iran Tel: +989143057376 Email: [email protected]